干细胞技术用于椎间盘再生的研究进展及挑战
Research progress and challenge of the stem cell therapy for intervertebral disc regeneration
摘要 背景:椎间盘退变与下腰痛密切相关,被认为是椎间盘突出症等椎间盘退行性疾病的病理基础,严重影响人们的生活质量.目前无论是保守治疗还是手术治疗都不能从根本上逆转或阻止椎间盘退变的病理发展.目的:归纳、总结近几年干细胞移植治疗退行性椎间盘疾病的研究进展,并分析所面临的挑战及潜在的解决方案.方法:通过检索数据库PubMed查阅2016年9月之前的相关文献,纳入干细胞移植治疗椎间盘退变在体外实验、动物实验及临床试验方面的相关研究,分析该疗法所面临的主要问题.结果与结论:①干细胞移植的生物学修复技术为椎间盘退行性疾病提供新的治疗策略,迄今已在大量体外实验及动物模型中开展研究,并逐渐跨越至临床试验阶段,均取得显著成果;②然而,如何使干细胞移植后适应退变椎间盘的微环境、选择何种干细胞、如何掌握治疗的适应证等一系列问题对研究人员提出巨大挑战.
Abstract:
BACKGROUND: Interverbral disc degeneration (IDD) is the major cause of low back pain, which is considered as the pathological basis of intervertebral disc herniation and other degenerative diseases that severely affect the patients' quality of life. At present, neither conservative treatment nor operative treatment can reverse or inhibit the pathological development of IDD.OBJECTIVE: To summarize the progress of stem cell therapy for IDD, and to further analyze its challenge and potential solutions.METHODS: Relevant studies in PubMed database published before September 2016 were retrieved. Studies about stem cell therapy in IDD in vitro and vivo as well clinical trials were enrolled to analyze its existing problems.RESULTS AND CONCLUSION: (1) Stem cell therapy provides a new strategy for IDD treatment. So far, a large number of studies in vitro and vivo as well as clinical trials have reported the remarkable effect of stem cell therapy. (2) However, problems such as how to deal with microenvironment of interverbral disc, choose proper stem cells and master indications will be a challenge in the future.
Author: Liang Hang Deng Xiang-yu Shao Zeng-wu
作者单位: 华中科技大学同济医学院附属协和医院骨科医院,湖北省武汉市,430022
刊 名 中国组织工程研究 ISTICPKU
年,卷(期): 2017, 21(19)
分类号: R318
在线出版日期: 2017年8月9日
基金项目: 科技部国家重点研发计划,基金号:2016YFC1100100,the National Key Research and Development Program of Ministry of Science and Technology, No.2016YFC1100100