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  • 抗精神病药已经有60余年的使用历史,应用于治疗精神分裂症及其他精神疾病伴随的幻觉、妄想症等症状。临床和动物研究都提示抗精神病药的长期使用会导致个体对药物的敏感性发生变化,即产生敏化或耐受效果。在急性用药情况下...
    抗精神病药敏化耐受条件躲避反应苯环利定诱发的运动增强antipsychotic drugsensitizationtoleranceconditioned avoidance responsePCP-induced hyperloco-motion
  • [外文期刊] Hendrickson HP Whaley EC Owens SM 《Journal of Mass Spectrometry》, ISTIC EI SCI PKU CSSCI 2005 1
    A liquid chromatographic/tandem mass spectrometric method is described for the determination of phencyclidine (PCP) in small volumes of rat serum (e.g. 50 microl). Samples were extracted using a mixed-...
    HallucinogensPhencyclidineSpectrometry, Mass, Electrospray Ionization致幻药苯环利定物质滥用检测
  • [外文期刊] Jenkins AJ Engelhart DA 《Journal of Analytical Toxicology》, ISTIC EI SCI PKU CSSCI 2006 8
    Historically, the chemical analysis of human nails has been used for detecting transition metals (1) and, in the last 20 years or so, drugs of abuse (2). Published articles have reported the presence o...
    Forensic ToxicologyHallucinogensNailsPhencyclidinePhencyclidine Abuse致幻药指(趾)甲苯环利定苯环利定滥用
  • [外文期刊] Mori A Noda Y Mamiya T Miyamoto Y Nakajima A Furukawa H Nabeshima T 《Behavioural Brain Research: An International Journal》, ISTIC EI SCI PKU CSSCI 2001 1
    The effects of several N-methyl-D-aspartate (NMDA) receptor- and sigma receptor-related compounds on the discriminative stimulus effects of phencyclidine (PCP) were examined in rats trained to discrimi...
    Discrimination Psychology drug effectsExcitatory Amino Acid Antagonists兴奋性氨基酸拮抗剂苯环利定受体N-甲基-D-天冬氨酸受体苯环利定受体Σ
  • [外文期刊] Espaze F Hamon J Hirbec H Vignon J Kamenka JM 《European Journal of Medicinal Chemistry: Chimie Therapeutique》, ISTIC EI SCI PKU CSSCI 2000 3
    Congeners of the potent dopamine (DA) re-uptake inhibitor 1-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP) are unexpectedly able to bind in the rat cerebellum, although this structure is devoid ...
    CerebellumDopamine AgonistsPhencyclidineReceptorsPhencyclidineExcitatory Amino Acid Antagonists小脑多巴胺激动剂苯环利定受体苯环利定
  • [外文期刊] Lim K Owens SM Arnold L Sacchettini JC Linthicum DS 《The Journal of biological chemistry》, ISTIC EI SCI PKU CSSCI 1998 44
    The crystal structure of monoclonal antibody (mAb) 6B5 Fab fragment complexed with 1-(1-phenylcyclohexyl)piperidine (PCP or phencyclidine) was determined at 2.2-A resolution. 6B5 was originally produce...
    AntibodiesMonoclonalImmunoglobulinsFabPhencyclidine抗体单克隆免疫球蛋白类Fab苯环利定
  • [外文期刊] Moriarty RM Enache LA Zhao L Gilardi R Mattson MV Prakash O 《Journal of Medicinal Chemistry》, ISTIC EI SCI PKU CSSCI 1998 4
    Three phencyclidine (PCP) analogues possessing a highly rigid carbocyclic structure and an attached piperidine ring which is free to rotate were synthesized. Each analogue has a specific fixed orientat...
    PhencyclidineReceptorssigmaReceptorsPhencyclidinesigma-1-receptor苯环利定受体Σ受体苯环利定
  • [外文期刊] Yoshikawa S Hareyama N Ikeda K Kurokawa T Nakajima M Nakao K Mochizuki H Ichinose H 《European Journal of Pharmacology: An International Journal》, ISTIC EI SCI PKU CSSCI 2009 1/3
    Abnormalities in dopaminergic and serotonergic neurotransmission in the forebrain are believed to be involved in the underlying mechanism of schizophrenia; therefore, the direct blockade of the recepto...
    TRK 820SchizophreniaReceptorsOpioidPhencyclidinestrategy精神分裂症受体阿片样苯环利定
  • [外文期刊] Sauer C Peters FT Schwaninger AE Meyer MR Maurer HH 《Biochemical Pharmacology》, ISTIC EI SCI PKU CSSCI 2009 3
    Investigations using insect cell microsomes with cDNA-expressed human cytochrome P450 (CYP)s and human liver microsomes (HLM) are reported on the CYP isoenzymes involved in the metabolism of the design...
    ChromatographyLiquidCytochrome P-450 Enzyme SystemDesigner DrugsGas Chromatography-Mass Spectrometry色谱法液相改制药物同工酶类苯环利定
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