抗精神病药敏化耐受条件躲避反应苯环利定诱发的运动增强antipsychotic drugsensitizationtoleranceconditioned avoidance responsePCP-induced hyperloco-motion
《Journal of Mass Spectrometry》,
A liquid chromatographic/tandem mass spectrometric method is described for the determination of phencyclidine (PCP) in small volumes of rat serum (e.g. 50 microl). Samples were extracted using a mixed-...
HallucinogensPhencyclidineSpectrometry, Mass, Electrospray Ionization致幻药苯环利定物质滥用检测
《Journal of Analytical Toxicology》,
Historically, the chemical analysis of human nails has been used for detecting transition metals (1) and, in the last 20 years or so, drugs of abuse (2). Published articles have reported the presence o...
Forensic ToxicologyHallucinogensNailsPhencyclidinePhencyclidine Abuse致幻药指(趾)甲苯环利定苯环利定滥用
《Behavioural Brain Research: An International Journal》,
The effects of several N-methyl-D-aspartate (NMDA) receptor- and sigma receptor-related compounds on the discriminative stimulus effects of phencyclidine (PCP) were examined in rats trained to discrimi...
Discrimination Psychology drug effectsExcitatory Amino Acid Antagonists兴奋性氨基酸拮抗剂苯环利定受体N-甲基-D-天冬氨酸受体苯环利定受体Σ
《European Journal of Medicinal Chemistry: Chimie Therapeutique》,
Congeners of the potent dopamine (DA) re-uptake inhibitor 1-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP) are unexpectedly able to bind in the rat cerebellum, although this structure is devoid ...
CerebellumDopamine AgonistsPhencyclidineReceptorsPhencyclidineExcitatory Amino Acid Antagonists小脑多巴胺激动剂苯环利定受体苯环利定
《The Journal of biological chemistry》,
The crystal structure of monoclonal antibody (mAb) 6B5 Fab fragment complexed with 1-(1-phenylcyclohexyl)piperidine (PCP or phencyclidine) was determined at 2.2-A resolution. 6B5 was originally produce...
《Journal of Medicinal Chemistry》,
Three phencyclidine (PCP) analogues possessing a highly rigid carbocyclic structure and an attached piperidine ring which is free to rotate were synthesized. Each analogue has a specific fixed orientat...
《European Journal of Pharmacology: An International Journal》,
Abnormalities in dopaminergic and serotonergic neurotransmission in the forebrain are believed to be involved in the underlying mechanism of schizophrenia; therefore, the direct blockade of the recepto...
Investigations using insect cell microsomes with cDNA-expressed human cytochrome P450 (CYP)s and human liver microsomes (HLM) are reported on the CYP isoenzymes involved in the metabolism of the design...
ChromatographyLiquidCytochrome P-450 Enzyme SystemDesigner DrugsGas Chromatography-Mass Spectrometry色谱法液相改制药物同工酶类苯环利定