METHODS AND COMPOSITIONS FOR CELLS EXPRESSING A CHIMERIC INTRACELLULAR SIGNALING MOLECULE

The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an chimeric antigen receptor and bispecific antibodies in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. Certain aspects include modified T cells and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.

申请(专利)号: EP20160842710
申请日期: 2016年8月26日
公开(公告)日: 2018年7月4日
公开(公告)号: EP3340995(A1)
主分类号: A61K35/12,A,A61,A61K,A61K35
分类号: A61K35/12,A61K35/17,A61P35/00,C07K16/30,C07K16/46,C12N15/13,A,C,A61,C07,C12,A61K,A61P,C07K,C12N,A61K35,A61P35,C07K16,C12N15
申请(专利权)人: The Trustees of The University of Pennsylvania,Wayne State University
发明(设计)人: JUNE, Carl H.,MILONE, Michael,ZHAO, Yangbing,LUM, Lawrence,THAKUR, Archana