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  • [发明专利]WO2002US25607 _ UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION LANDFIELD, PHILIP, W. BLALOCK, ERIC, M. CHEN, KUEY-CHU FOSTER, THOMAS, C. 2002年08月13日
    The invention relates to genetic algorithms for identifying gene expression profile biomarkers for brain aging which may be correlated with behavioral tests. Statistical and functional correlation strategy is implemented to identify changes in cellula...
  • [发明专利]WO2002DE04053 _ EPIGENOMICS AG BERLIN, KURT ROY, DEBJANI 2002年10月25日
    The invention relates to a method for analysis of methylation models in genomic DNA. In contrast to conventional methods for the analysis of methylation models, said method comprises a two-part method, whereby the genomic DNA is firstly subjected to a...
  • [发明专利]WO2002US31988 _ CASE WESTERN RESERVE UNIVERSITY MARKOWITZ, SANFORD, D. 2002年10月07日
    This application describes methods and compositions for detecting and treating HLTF-associated neoplasia. Differential mehylation of the HLTF nucleotide sequences has been observed in HLTF-associated neoplasia such as colon neoplasia.
  • [发明专利]WO2002US22904 _ THE GENERAL HOSPITAL CORPORATION FISHMAN, MARK, C. MAYER, ALAN, N. 2002年07月17日
    The invention provides methods of diagnosing diseases and conditions of the digestive system and cancer, methods for identifying compounds that can be used to treat or to prevent such diseases and conditions, and methods of using these compounds to t...
  • [发明专利]WO2002US20417 _ MOUNTAIN VIEW PHARMACEUTICALS, INC. 2002年06月28日
    Methods are provided for the stabilization of proteinases by the covalent attachment of or admixture with water-soluble polymers. The resultant stabilized proteinases have increased stability under the harsh conditions used in industrial genomics, whi...
  • [发明专利]WO2002ES00603 _ CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS UNIVERSIDAD POLITECNICA DE CATALUNA INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE-FRANCE CAMARERO FERANDEZ, SUSANA GARCIA, OLGA VIDAL, TERESA COLOM, JOSE, F. RIO, JOSE, C., DEL GUTIERREZ SUAREZ, ANA MARTINEZ HERNANDEZ, MARIA, JESUS SIGOILLOT, JEAN, C. ASTHER, MARCEL MARTINEZ FERRER, ANGEL, TOMAS 2002年12月17日
    The invention relates to a method of bleaching high-quality paper pulps, which are obtained from herbaceous or shrub plants (flax, hemp and kenaf, among others), using a lacasse-type ligninolytic enzyme in the presence of redox mediators. Said pulps, ...
  • [发明专利]WO2002US21322 _ ELI LILLY AND COMPANY JIA, AUDREY, YUNHUA TSURUSHITA, NAOYA VASQUEZ, MAXIMILIANO, J. 2002年08月14日
    This invention provides variant 266 antibodies that are engineered to lack an N-glycosylation site within the CDR2 of the heavy chain, pharmaceutical compositions thereof, and polynucleotide sequences, vectors, and transformed cells useful to express ...
  • [发明专利]WO2002US02455 _ THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE 2002年01月28日
    The invention is directed to a method of diagnosing a cell proliferative disorder of breast tissue by determining the methylation status of nucleic acids obtained from a subject. Aberrant methylation of several genes including TWIST, HOXA5, NES-1, ret...
  • [发明专利]WO2002US01287 _ DAI, ZIYU SHI, LIFANG HOOKER, BRIAN, S. 2002年01月18日
    There are disclosed novel pin1 gene promoter isoforms and amt gene promoter isoforms. The promoters and their functional elements amy be used independently or in combination with one or more enhancer elements to increase or otherwise manipulate gene e...
  • [发明专利]WO2002US09928 _ APPLIED MINDS, INC. 2002年03月27日
    Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to reduce the number of hybridizing nucleotide sequences or pr...
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