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2024年3期
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Assay of Biomarkers for Alzheimer's Disease by Surface Plasmon Resonance
Assay of Biomarkers for Alzheimer's Disease by Surface Plasmon Resonance
摘要
Alzheimer's disease(AD)is one of the neurodegenerative diseases characterized by cognitive dysfunction and behavioral impairment.Early diagnosis of AD serves as a viable means to avoid the onset and progression of the disease.Due to the remarkably lower expression levels of AD biomarkers in cerebrospinal fluids and serum samples,sensitive and specific analytical methods are highly demanded.Surface plasmon resonance(SPR)is ultrasensitive to the refractive index or thick-ness change at the metal surface,which enables real-time and label-free assay of target biomolecules.In this review,we summarize the advances on assay of AD biomarkers including amyloid beta,tau protein,apoE proteins and apoE genes,and BACE1 by SPR,with emphasis on the analytical performances concerning anti-fouling and signal amplification strategies and real sample applications.
Author：
Xinyao Yi
Huihui Chen
Yuhan He
Jianxiu Wang
作者单位：
Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China
年，卷(期)：
2024, 8(3)
机标分类号：
R749.1
R2
R96
在线出版日期：
2024年11月27日
