基于金纳米花的微流控电化学传感检测多巴胺
Microfluidic electrochemical sensing device based on gold nanoflower for dopa-mine detection
摘要
设计了一种基于金纳米花修饰电极的微流控电化学传感装置,用于细胞分泌多巴胺(DA)的检测.实验表明,经金纳米花修饰的电极对DA的检测性能有了极大提升,且不受抗坏血酸,尿酸,葡萄糖等干扰物的影响.该微流控电化学传感装置对DA的线性响应范围为0.2～20 µmol/L,检测限为0.16 µmol/L,并成功实现了对神经母瘤细胞分泌DA的检测.
A gold nanoflower-modified microfluidic electrochemical biosensing device for the detection of dopamine(DA)secretion from cell was established.Experimental results demonstrated that the gold nanoflower-modified electrode significantly enhanced DA sensing performance and had a good selectivity for the detection of DA without interfering from ascorbic acid,uric acid,and glucose.The microfluidic electrochemical biosensing device achieved a linear detection range of 0.2‒20 µmol/L for DA,with the limit of detection of 0.16 µmol/L.Furthermore,the microfluidic electrochemical biosensing device successfully achieved the detection of DA secretion from neuroblastoma cells.
年，卷(期)：
2026, 45(7)
分类号：
TP212.3
机标分类号：
TB383
TQ450.2+63
O657.1
在线出版日期：
2026年7月30日
基金项目：
61971302:国家自然科学基金，
