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2026年7期
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Engineered Subcutaneous Site for Optimal Organoid Transplantation
Engineered Subcutaneous Site for Optimal Organoid Transplantation
摘要
The subcutaneous space is an advantageous site for cell transplantation because of its minimally invasive accessibility.However,poor vascularization often compromises cell survival,leading to significant apop-tosis of transplanted cells.To address this limitation,we engineered a pre-vascularized niche by subcu-taneously implanting polyvinyl chloride(PVC)catheters into rodent models.Foreign body reactions elicited by PVC catheters recruited reparative immune cells,which secreted pro-angiogenic factors to induce robust neovascularization.The subsequent transplantation of stem cell-derived vascular orga-noids into this engineered niche resulted in optimal engraftment,forming functional,perfused human blood vessels.In a proof-of-concept islet transplantation model,even a marginal dose of islets rapidly restored normoglycemia,which was attributed to enhanced graft revascularization.Collectively,our find-ings demonstrate a simple yet effective strategy for overcoming the vascular limitations of subcutaneous cell transplantation,offering promising potential for clinical applications.
年，卷(期)：
2026, 62(7)
机标分类号：
R531.3
R711
在线出版日期：
2026年9月10日
