As a natural adsorption material,red soil has obvious advantages of wide source and low cost,and has broad application prospects for antibiotic removal in water environment.In this study,adsorption-desorption of vancomycin(VAN)from wastewater on red soil was investigated in a batch system.The influencing factors of the adsorption of vancomycin were analyzed,and the adsorption mechanism was explored by kinetic and isothermal adsorption models.Besides,the response characteristics of this method in actual wastewater were investigated.Results showed that the adsorption efficiency increases first and then becomes stable with the increase of red soil concentration.The optimal concentration of red soil is 20 g/L.The higher pH lead to increased adsorption efficiency,and the maximum adsorption rate was 98.09%.With the increase of coexisting ion concentration,the adsorption rate showed an obvious downward trend,and the inhibition effect of Ca2+was the strongest.The good fitting of both pseudo-first-order and pseudo-second-order kinetic models indicates that the adsorption process in red soil is jointly controlled by physical and chemical reactions.Both Freundlich model and Langmuir model are suitable for describing the adsorption characteristics of vancomycin in red soil,indicating that multimolecular layer adsorption and single-molecular layer adsorption exist simultaneously,and the theoretical maximum adsorption capacity is 9.22 mg/g.The response characteristics of this method in actual wastewater are manifested as achieving a good removal effect after prolonging the reaction time.In the pilot-scale system,the adsorption rate is 81.21%after 6 h.This research can provide a reliable solution for the removal of vancomycin in the environment.