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2024年1期
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Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441
Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441
摘要
The biological effects of magnetic fields(MFs)have been a controversial issue.Fortunately,in recent years,there has been increasing evidence that MFs do affect biological systems.However,the physical mechanism remains unclear.Here,we show that MFs(16 T)reduce apoptosis in cell lines by inhibiting liquid-liquid phase separation(LLPS)of Tau-441,suggesting that the MF effect on LLPS may be one of the mechanisms for understanding the"mysterious"magnetobiological effects.The LLPS of Tau-441 occurred in the cytoplasm after induction with arsenite.The phase-separated droplets of Tau-441 recruited hexokinase(HK),resulting in a decrease in the amount of free HK in the cytoplasm.In cells,HK and Bax compete to bind to the voltage-dependent anion channel(VDAC I)on the mitochondrial membrane.A decrease in the number of free HK molecules increased the chance of Bax binding to VDAC I,leading to increased Bax-mediated apoptosis.In the presence of a static MF,LLPS was marked inhibited and HK recruitment was reduced,resulting in an increased probability of HK binding to VDAC I and a decreased probability of Bax binding to VDAC I,thus reducing Bax-mediated apoptosis.Our findings revealed a new physical mechanism for understanding magnetobiological effects from the perspective of LLPS.In addition,these results show the potential applications of physical environments,such as MFs in this study,in the treatment of LLPS-related diseases.
Author：
Wen-Juan Lin
Wen-Pu Shi
Wan-Yi Ge
Liang-Liang Chen
Wei-Hong Guo
Peng Shang
Da-Chuan Yin
作者单位：
Key Laboratory for Space Bioscience and Biotechnology,School of Life Sciences,Northwestern Polytechnical University,127 Youyixi Road,Xi'an 710072,Shaanxi,PR China
年，卷(期)：
2024, 2024(1)
机标分类号：
P746
TP301
R733.7
在线出版日期：
2024年4月15日
