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中草药（英文版）
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2026年3期
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Amentoflavone:A safe and novel penetration enhancer for transdermal applications
Amentoflavone:A safe and novel penetration enhancer for transdermal applications
摘要
Objective:Most of existing chemical penetration enhancers are along with obvious toxicity and skin irri-tation,new penetration enhancer is still to be developed yet.Amentoflavone is a flavonoid compound extracted from plant Selaginella tamariscina with high biocompatibility.However,its efficacy of penetra-tion enhancers has not been studied.
Methods:For the first time,the influence of amentoflavone to the skin penetration of caffeine was inves-tigated by the Franz diffusion cells.The interactions of amentoflavone with the skin lipid and keratin were determined to identify the underlying mechanisms by the Fourier transform infrared spectroscopy(FTIR),differential scanning calorimetry(DSC),etc.
Results:Results showed that the penetration enhancement ratio(ER)of amentoflavone to model com-pound caffeine is nearly three times.The major mechanism was identified to be contributed to that,amentoflavone can not only change the keratin structure in stratum corneum(SC),but also undergo hydration interactions with intradermal components,therefore dissolving the lipid,loosening and reduc-ing the barrier function of SC.
Conclusion:These results give new evidence to the potential of amentoflavone as the novel effective chemical enhancer for the skin meditated delivery of external molecules,and it can exert the dual effects of traditional Chinese medicine activity and penetration enhancement.
年，卷(期)：
2026, 18(3)
机标分类号：
O643
TP273
X820.3
在线出版日期：
2026年8月26日
