The'non-conventional'peptidome:A new layer in plant regulatory mechanisms
摘要
A substantial but largely unexplored fraction of eukaryotic proteomes is composed of peptides and small proteins(the peptidome).In recent years,short open reading frames(sORFs)capable of encoding func-tional peptides have been identified within transcripts annotated as non-coding RNAs or in intergenic re-gions.These sORF-encoded peptides(SEPs)were previously overlooked due to their small size and diffi-culties in detection,both experimentally and computationally.However,analyses of translating RNAs(ribosome profiling)and proteomics(mass spectrometry)have provided growing evidence for the exis-tence of numerous novel'non-conventional'peptides in eukaryotic organisms,including plants.In animals,mounting evidence indicates that long non-coding RNAs are an important source of SEPs,and that SEPs participate in crucial cellular and physiological processes and can mediate the evolution of novel charac-teristics.Similar findings are now emerging in plants.The SEP-coding capacity and the full repertoire of functional SEPs within eukaryotic genomes remain unclear,but systematic,large-scale molecular screen-ings are beginning to address this gap.Here,we review current progress in understanding the plant non-conventional peptidome,explore parallels between plants and animals,and illustrate how findings in animals can help guide plant research on this topic.
年，卷(期)：
2025, (12)
机标分类号：
TP316
S
Q943
在线出版日期：
2026年4月27日
