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[发明专利]US20260265956A1 _
10x Genomics, Inc.
2026年04月24日
The disclosure provides systems and methods for droplet processing. For example, a method can include providing a first droplet and a second droplet. In some cases, the first droplet may have a first concentration of a reagent and the second droplet may have a second concentration of the reagent. The second droplet may comprise a bead or a biological particle. The method can also include subjecting the first droplet and the second droplet to conditions sufficient to transfer the reagent from the first droplet to the second droplet, thereby decreasing the first concentration in the first droplet and increasing the second concentration in the second droplet.
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[发明专利]JP2026111628A _
株式会社カネカ
2024年12月24日
[Problem] To provide a method for efficiently selecting peptides that have high affinity for a target molecule and that possess functionality. [Solution] A peptide screening method comprising the following steps: (1) A step of reacting a functional crosslinking agent with a peptide to form a peptide complex having a structure in which the peptide and the functional crosslinking agent are crosslinked intermolecularly. (2) A step of mixing the peptide complex obtained in step (1) with a target molecule and selecting the peptide complex bound to the target molecule. [Selected Figure] None
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[发明专利]WO2026165193A3 _
MASSACHUSETTS INSTITUTE OF TECHNOLOGY THE GENERAL HOSPITAL CORPORATION
2026年01月29日
Combinatorial peptide libraries, as well as associated systems and methods, are generally described.
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[发明专利]US12612714B2 _
10x Genomics, Inc.
2025年07月28日
The disclosure provides systems and methods for droplet processing. For example, a method can include providing a first droplet and a second droplet. In some cases, the first droplet may have a first concentration of a reagent and the second droplet may have a second concentration of the reagent. The second droplet may comprise a bead or a biological particle. The method can also include subjecting the first droplet and the second droplet to conditions sufficient to transfer the reagent from the first droplet to the second droplet, thereby decreasing the first concentration in the first droplet and increasing the second concentration in the second droplet.
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[发明专利]EP4745278A2 _
ILLUMINA, INC.
2018年11月05日
Presented herein are techniques for indexing of nucleic acid, e.g., for use in conjunction with sequencing. The techniques include generating indexed nucleic acid fragments from an individual sample, whereby the index sequence incorporated into each index site of the nucleic acid fragment is selected from a plurality of distinguishable of index sequences and such that the population of generated nucleic acid fragments represents each index sequence from the plurality. In this manner, the generated indexed nucleic acid fragments from a single sample are indexed with a diverse mix of index sequences that reduce misassignment due to index read errors associated with low sequence diversity.
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[发明专利]US12692627B2 _
SEOUL NATIONAL UNIVERSITY Rx26;DB FOUNDATION KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
2022年02月28日
The present invention relates to a method of identifying an intracellular secretory protein or tissue-specific secretory protein, by using a proximity labeling system. When the method according to the present invention is used, it is possible to clearly identify an intracellular secretory protein and to dynamically track the spatiotemporal dynamics of a secretory protein secreted from a specific tissue in a living subject such that it can be effectively utilized for the research on endocrine signals between tissues, and particularly, since it can be applied in situ, the scope of application can be further expanded. Therefore, the present invention can be applied to various disease models or tissues to discover new biomarkers and therapeutic target proteins associated with diseases.
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[发明专利]US12668893B2 _
The Board of Trustees of the Leland Stanford Junior University
2022年08月24日
Processes and materials to detect neoplasms from a biopsy are described. Processes and materials to build a sequencing library are described. Processes and material to perform targeted sequencing are described. Processes and materials to mitigate confounding sources are described. Cell-free nucleic acids can be sequenced and the sequencing result can be utilized to detect sequences derived from a neoplasm.
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[发明专利]US12735810B2 _
10x Genomics, Inc.
2026年04月24日
The disclosure provides systems and methods for droplet processing. For example, a method can include providing a first droplet and a second droplet. In some cases, the first droplet may have a first concentration of a reagent and the second droplet may have a second concentration of the reagent. The second droplet may comprise a bead or a biological particle. The method can also include subjecting the first droplet and the second droplet to conditions sufficient to transfer the reagent from the first droplet to the second droplet, thereby decreasing the first concentration in the first droplet and increasing the second concentration in the second droplet.
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[发明专利]CN121675084A _
深圳市小分子新药创新中心有限公司
2024年09月14日
本发明提供了一种快速、实时监控的从噬菌体文库中垂钓抗体的方法。相对于传统噬菌体文库需经3轮淘洗来富集阳性克隆，本发明方法仅需一步即可垂钓得到阳性克隆，并且能够实时监控噬菌体展示抗体与抗原的结合和解离、及时剔除低亲和力克隆；快速、准确提高筛选的成功率。具体步骤包括：将抗原固化至BLI传感器表面；浸入噬菌体文库垂钓噬菌体展示抗体；高强度洗涤条件去除非特异性结合的克隆，降低噬菌体高粘度引起的高噪声而导致的筛选失败；对垂钓得到的克隆进行信号放大，避免低响应值导致的无法测量；洗脱得到传感器上特异性结合的克隆；对垂钓得到的克隆进行单克隆噬菌体ELISA验证。
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[发明专利]BR112013001175B1 _
ADIMAB, LLC
2011年07月14日
METHOD FOR MAKING SYNTHETIC POLYNUCLEOTIDE LIBRARIES, POLYNUCLEOTIDE LIBRARIES, LIBRARY POLYPEPTIDE EXPRESSION PRODUCTS, ANTIBODY, VECTOR, KIT, HOST CELL AND USE OF SAID LIBRARY. The present invention overcomes the shortcomings inherent in known methods for generating antibody-coding polynucleotide libraries by specifically designing libraries with targeted sequence and length diversity.
